Even partial loss of the gene impairs the mouse brain’s ability to respond to sensory experiences, which may explain why people with SYNGAP1 mutations tend to have learning difficulties and a high pain tolerance.

The post Autism-linked gene SYNGAP1 molds synaptic plasticity, learning appeared first on Spectrum | Autism Research News.

The possibility of microbial treatments for autism has inspired a burst of research and nascent clinical trials, but new research suggests these efforts rest on shaky scientific ground.

The post Despite flurry of findings, doubts dog gut microbes’ role in autism appeared first on Spectrum | Autism Research News.

A drug that helps promote gene expression reduces repetitive behaviors and improves memory and sociability in a mouse model of autism.

The post Cancer drug alters autism-like traits in mice appeared first on Spectrum | Autism Research News.

The first animal model of MYT1L syndrome suggests that fast-maturing neurons lead to the unusually small brains, social deficits and other traits seen in people with the condition.

The post Precocious neurons may stunt brain growth in rare form of autism appeared first on Spectrum | Autism Research News.

Mice exposed to unusually low levels of the placental hormone allopregnanolone in the womb show atypical brain development and autism-like behaviors.

The post Placental hormone loss spurs autism-like traits in mice appeared first on Spectrum | Autism Research News.

Altered electrical activity in the neurons of mice with a mutated copy of SCN2A may explain the animals’ autism-like social behaviors.

The post Model mice hint at sodium channel gene’s contribution to autism appeared first on Spectrum | Autism Research News.

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

The post Disruptions to brain’s ‘thermostat’ may underpin autism traits appeared first on Spectrum | Autism Research News.

The finding that MDMA and an experimental serotonin agonist increase sociability across six different model mice suggests that disparate autism-linked mutations converge on the same underlying pathways.

The post Drugs boost serotonin, socialization in multiple autism mouse models appeared first on Spectrum | Autism Research News.

Deleterious mutations in an autism-associated gene can make neurons hyperexcitable, raising the risk of epileptic seizures.

The post How mutations in top autism gene could lead to seizures appeared first on Spectrum | Autism Research News.

Neurons in mice with an autism-linked mutation sprout extraneous protrusions, an overgrowth accompanied by above-average motor learning. Inhibiting a cell signaling pathway reverses the effect.

The post Blocking key pathway reverses brain, behavior changes in autism mouse model appeared first on Spectrum | Autism Research News.