Even partial loss of the gene impairs the mouse brain’s ability to respond to sensory experiences, which may explain why people with SYNGAP1 mutations tend to have learning difficulties and a high pain tolerance.

The post Autism-linked gene SYNGAP1 molds synaptic plasticity, learning appeared first on Spectrum | Autism Research News.

Preliminary results suggested the treatment is no better than placebo at reducing the severity of core autism traits.

The post French pharma firms terminate trials of bumetanide for autism appeared first on Spectrum | Autism Research News.

Mounting evidence suggests that autism often involves upsets in homeostatic plasticity, a set of processes neurons use to stabilize their activity. These disruptions result from a range of autism-linked mutations and may help to explain the condition’s famed heterogeneity.

The post Disruptions to brain’s ‘thermostat’ may underpin autism traits appeared first on Spectrum | Autism Research News.

A transplant of inhibitory neurons during the second week of life prevents social difficulties and a brain signaling imbalance in mice missing a copy of FOXG1.

The post Critical time window flagged for autism gene’s influence appeared first on Spectrum | Autism Research News.